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When medications for attention-deficit hyperactivity disorder ADHD became available, parents everywhere breathed a collective sigh of relief that their children would finally be able to enjoy a relatively normal social and academic experience. These children and teens were often labeled as behavioral problems because the symptoms of ADHD—impulsivity; inability to pay attention, follow instructions, or sit still; distractibility—can lead to problems at school and outside of the classroom. Indeed, ADHD drugs have the potential to benefit those who need them by reducing the risks for injuries and car accidents. Research suggests these agents may be protective later in life against developing drug and alcohol abuse, although the evidence for this is somewhat in flux. Many ADHD drugs act by stimulating such chemical neurotransmitters in the brain as dopamine and epinephrine. Adjusting neurotransmitter levels can be highly effective in treating such disorders as ADHD, depression, and anxiety. Some of the most familiar ADHD medicines, called methylphenidates, fall into this category. They work by boosting neurotransmitters. Common stimulants include methylphenidate Concerta, Ritalin, Metadate, Daytrana and dexmethylphenidate Focalin.

Toxicol Allied Clin Pharmacol 1 1: This is an Open Access article published and distributed under the terms of the Creative Commons Attribution License, that permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. Patients experiencing toxicity from these drugs frequently present to the emergency department and may have serious consequences from their hyperadrenergic state, such as acute coronary syndrome, stroke, acute heart and renal failure. Objective of the Review: Medical management of these patients has changed over time as new therapies have been developed, with control of agitation and hyperadrenergic state being the top priorities to prevent secondary injuries. Control of agitation with benzodiazepines and antipsychotics is an important first step but may not alleviate the tachycardia, hypertension, and hyperthermia these patients often experience. Unlike cocaine, the half-lives of these drugs are several hours with increased potential for pathologic sequelae.

We read every letter or e-mail we receive, and we will convey your comments to CIA officials outside OPA as appropriate. However, with limited staff and resources, we simply cannot respond to all who write to us. Submit questions or comments online.

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