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Welcome sign in sign up. The National Institute on Drug Abuse estimates that 72, Americans died from drug overdoses in , up from some 64, the previous year and 52, the year before that—a staggering increase with no end in sight. Most involved opioids. A few definitions are in order. The term opioid is now used to include opiates, which are derivatives of the opium poppy, and opioids, which originally referred only to synthesized drugs that act in the same way as opiates do. Opium, the sap from the poppy, has been used throughout the world for thousands of years to treat pain and shortness of breath, suppress cough and diarrhea, and, maybe most often, simply for its tranquilizing effect.

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