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Non si conosce pienamente il modo in cui gli antidepressivi agiscono, tuttavia essi possono essere d'aiuto innalzando i livelli di serotonina e noradrenalina nel cervello. Se utilizza altri medicinali che, assunti insieme ad Efexor possono far aumentare il rischio di sviluppare una sindrome serotoninergica vedere il paragrafo "Assunzione di Efexor con altri medicinali".
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